Dose evaluation of lamivudine in human immunodeficiency virus-infected children aged 5 months to 18 years based on a population pharmacokinetic analysis

作者：Janssen Esther J H; Bastiaans Diane E T; Valitalo Pyry A J; van Rossum Annemarie M C; Jacqz Aigrain Evelyne; Lyall Hermione; Knibbe Catherijne A J^*; Burger David M

来源：British Journal of Clinical Pharmacology, 2017, 83(6): 1287-1297.

DOI：10.1111/bcp.13227

• human immunodeficiency virus/acquired immune deficiency syndrome
• modelling and simulation
• paediatrics
• pharmacotherapy
• therapeutic drug monitoring

AIM
The objectives of this study were to characterize age-related changes in lamivudine pharmacokinetics in children and evaluate lamivudine exposure, followed by dose recommendations for subgroups in which target steady state area under the daily plasma concentration-time curve (AUC(0-24h)) is not reached.
METHODS
Population pharmacokinetic modelling was performed in NONMEM using data from two model-building datasets and two external datasets [n = 180 (age 0.4-18 years, body weight 3.4-60.5 kg); 2061 samples (median 12 per child); daily oral dose 60-300 mg (3.9-17.6 mg kg(-1))]. Steady state AUC(0-24h) was calculated per individual (adult target 8.9 mg.hl(-1)).
RESULTS
A two-compartment model with sequential zero order and first order absorption best described the data. Apparent clearance and central volume of distribution (% RSE) were 13.2 lh(-1) (4.2%) and 38.9l (7.0%) for a median individual of 16.6 kg, respectively. Bodyweight was identified as covariate on apparent clearance and volume of distribution using power functions (exponents 0.506 (20.2%) and 0.489 (32.3%), respectively). The external evaluation supported the predictive ability of the final model. In 94.5% and 35.8% of the children with a body weight >14 kg and <14 kg, respectively, the target AUC(0-24h) was reached.
CONCLUSION
Bodyweight best predicted the developmental changes in apparent lamivudine clearance and volume of distribution. For children aged 5 months-18 years with a body weight <14 kg, the dose should be increased from 8 to 10 mg kg(-1) day(-1) if the adult target for AUC(0-24h) is aimed for. In order to identify whether bodyweight influences bioavailability, clearance and/or volume of distribution, future analysis including data on intravenously administered lamivudine is needed.

• 出版日期2017-6