Absent Adrenarche in Children with Hypopituitarism: A Study Based on Urinary Steroid Metabolomics

作者：Boettcher Claudia^*; Hartmann Michaela F; de Laffolie Jan; Zimmer Klaus Peter; Wudy Stefan A

来源：Hormone Research in Paediatrics, 2013, 79(6): 356-360.

DOI：10.1159/000351705

• Absent adrenarche
• Adrenarche
• Hypopituitarism
• Urinary steroid metabolomics

Background: Up to now, the regulation of adrenarche remains a myth although ACTH may possibly play an important role. Methods: Urinary steroid profiling by gas chromatography-mass spectrometry was used to study non-invasively the adrenarchal steroid metabolome in 13 children aged 6-16 years with partial or complete hypopituitarism (HP) whose ACTH/cortisol axis was affected and compared it with 24 healthy age-matched controls. The sum of DHEA, 16 alpha-hydroxy-DHEA and 3 beta, 16 alpha, 17 beta-androstenetriol served as markers for adrenarche parameters (AP). The excretion rates of major urinary cortisol metabolites were also determined. Results: The excretion rates for AP were significantly lower for the HP subjects than for the controls (p %26lt; 0.001). After dividing the HP group into a subgroup treated with hydrocortisone (HC) and an HC-untreated subgroup, a significant difference for AP remained for each subgroup when compared to the control group (p %26lt; 0.001 and p = 0.045, respectively). Treatment with HC had no influence on AP. Conclusion: The data imply indirectly a significant contribution of ACTH to the regulation of adrenarche. Our results also signify important diagnostic information: absent adrenarche can be indicative of ACTH deficiency.

• 出版日期2013