Adiposity and fat distribution in relation to inflammation and oxidative stress in a relatively lean population of Chinese women

作者：Wu Sheng Hui; Shu Xiao Ou; Chow Wong Ho; Xiang Yong Bing; Zhang Xianglan; Cai Qiuyin; Li Hong Lan; Milne Ginger; Wen Wanqing; Ji Bu Tian; Rothman Nathaniel; Gao Yu Tang; Zheng Wei; Yang Gong^*

来源：Disease Markers, 2013, 34(4): 279-293.

DOI：10.3233/DMA-130969

• Adiposity
• inflammation
• oxidative stress
• biomarker

OBJECTIVES: This study evaluated associations of various anthropometric measures of adiposity with a panel of inflammatory and oxidative stress markers in a relatively lean population of Chinese women.
METHODS: This analysis included 1,005 Chinese women aged 40-70 years. Plasma concentrations of inflammatory and oxidative stress markers were measured. Anthropometric measurements were taken by trained interviewers.
RESULTS: Body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) were all positively and linearly associated with the inflammatory markers, CRP, TNF-alpha, soluble TNF-receptor 1 (sTNF-R1), and IL-6. A significant positive association of these measures of adiposity with the oxidative stress marker F-2-IsoP-M, a metabolite of F-2-IsoPs, but with not F-2-IsoPs was found. Differences in biomarkers between extreme quartiles of anthropometric measurements varied widely, ranging from 9.7% for sTNF-R1 to 162.0% for CRP. For each specific biomarker, various anthropometric measurements exhibited similar ability to explain variations in the biomarker, with the biggest partial r(2)(11%) observed for CRP.
CONCLUSIONS: This study suggests that both general adiposity (measured by BMI) and central adiposity (measured by WC and WHtR) are positively and similarly associated with various markers of inflammation and oxidative stress in relatively lean Chinese women. The metabolite F-2-IsoP-M of F-2-IsoPs may be a better marker of in vivo oxidative stress than its parent compounds.

• 出版日期2013
• 单位上海市肿瘤研究所