Anaplasma phagocytophilum, interferon gamma production and Stat1 signaling

作者：Choi Kyoung Seong; Dumler J Stephen^*

来源：Microbiology and Immunology, 2013, 57(3): 207-212.

DOI：10.1111/1348-0421.12023

• Anaplasma phagocytophilum
• gamma interferon
• signal transducer and activator of transcription 1

Human granulocytic anaplasmosis is caused by the obligate intracellular bacterium, Anaplasma phagocytophilum. The proinflammatory cytokine, IFN-, is necessary for innate immunity and plays an important role in the induction of severe histopathology in A. phagocytophilum-infected mice, horses and humans. In this study, activation of signal transducer and activator of transcription (Stat) 1 phosphorylation associated with A. phagocytophilum infection was examined in mice and found to be markedly greater on day 7 post-infection than in mock-infected controls. This increase in phosphorylated Stat1 (pStat1) correlated significantly with IFN- production and inflammatory tissue injury. Because pStat1 operates as a transcription factor central to the generation of effectors of inflammatory injury, these data suggest that Stat1 signaling is involved in IFN--mediated immunopathologic lesions and disease in A. phagocytophilum infection and could be an important target for intervention in this disease.

• 出版日期2013-3