Association of past and recent major depression and menstrual characteristics in midlife: Study of Women%26apos;s Health Across the Nation

作者：Bromberger Joyce T^*; Schott Laura L; Matthews Karen A; Kravitz Howard M; Randolph John F Jr; Harlow Sioban; Crawford Sybil; Green Robin; Joffe Hadine

来源：Menopause-The Journal of the North American Menopause Society, 2012, 19(9): 959-966.

DOI：10.1097/gme.0b013e318248f2d5

• Major depression
• Bleeding
• Menstrual cycle
• Midlife

Objective: The aim of this study was to examine the association of a history of major depression (MD) with menstrual problems in a multiethnic sample of midlife women. %26lt;br%26gt;Methods: Participants were 934 women enrolled in the Study of Women%26apos;s Health Across the Nation, a multisite study of menopause and aging. The outcomes were menstrual bleeding problems and premenstrual symptoms in the year before study entry. The Structured Clinical Interview for the Diagnosis of DSM-IV Axis I Disorders was conducted to determine recent and past psychiatric diagnoses. Covariates included sociodemographic, behavioral, and gynecologic factors. %26lt;br%26gt;Results: One third of the participants reported heavy bleeding, 20% reported other abnormal bleeding, and 18% reported premenstrual symptoms. One third had past and 11% had recent MD. Past MD was associated with an increased likelihood of heavy bleeding (odds ratio, 1.89; 95% CI, 1.25-2.85), adjusting for recent MD, menopause status, and other covariates. Past MD was not associated with other abnormal bleeding or premenstrual symptoms in the final analysis that adjusted for recent MD. %26lt;br%26gt;Conclusions: Midlife women with a history of MD are more likely to report heavy bleeding.

• 出版日期2012-9