Decreasing pro-inflammatory cytokine and reversing the immunosenescence with extracts of Pu-erh tea in senescence accelerated mouse (SAM)

作者：Zhang, Liang; Shao, Wan-fang; Yuan, Li-feng; Tu, Peng-fei; Ma, Zhi-zhong^*

来源：Food Chemistry, 2012, 135(4): 2222-2228.

DOI：10.1016/j.foodchem.2012.07.033

• Immunosenescence
• Naive T lymphocytes
• NK cells
• Interleukin-6
• Pu-erh tea
• Immune function

Immunosenescence, the progressive decline of adaptive immunity and chronic inflammation with ageing has been demonstrated to be the main factor responsible for infections, cancer and autoimmune conditions in the elderly. Senescence-accelerated mouse (SAM) was used to study the protective effects of Pu-erh tea in the elderly. The senile-prone sub-strain, SAM-P8 mice were administered individually with ripened or crude Pu-erh tea at 125, 250 or 500 mg/kg. The results showed that Pu-erh tea significantly increased the fractions of naive T lymphocytes, CD8(+)CD28(+) T lymphocytes and NK cells in the peripheral blood, but decreased the levels of IL-6 in aged mice. These data suggested that the Pu-erh tea reversed the immunosenescence by restoring the immune deficiency and decreasing pro-inflammatory cytokine. Thus, long term drinking of Pu-erh tea may be beneficial for the aged population in terms of increasing the body's resistance to infection and cancer.

• 出版日期2012-12-15
• 单位北京大学; 云南农业大学