Molecular Mechanisms of Macrolide Resistance in Clinical Isolates of Mycoplasma pneumoniae from China

作者:Xin Deli*; Mi Zuhuang; Han Xu; Qin Ling; Li Jing; Wei Tianli; Chen Xiaogeng; Ma Shaojie; Hou Ancun; Li Gui; Shi Dawei
来源:Antimicrobial Agents and Chemotherapy, 2009, 53(5): 2158-2159.
DOI:10.1128/AAC.01563-08

摘要

Fifty clinical Mycoplasma pneumoniae strains were isolated from 370 children with respiratory tract infections. Four strains were susceptible to macrolides, while the other 46 (92%) were macrolide resistant. The molecular mechanism of resistance was shown to be associated with point mutations in 23S rRNA at positions 2063 and 2064.