Anti-Ge3 causes late-onset hemolytic disease of the newborn: the fourth case in three Hispanic families

作者：Pate Lisa Lee; Myers Jessica C; Palma Jonathan P; Viele Maurene; Galel Susan A; Ferrer Zenaida; Gonzalez Christopher L; Benitz William E; Garratty George; Fontaine Magali J^*

来源：Transfusion, 2013, 53(10): 2152-2157.

DOI：10.1111/trf.12027

BackgroundThe Gerbich (Ge) blood group system consists of 11 antigens carried on red blood cell (RBC) membrane glycophorins C and D; of these, Ge:3 antigen is of high prevalence, and the anti-Ge3 is found to be clinically significant.
Case ReportA 34-week neonate born to a Hispanic mother with anti-Ge3 developed late-onset hemolysis with hyperbilirubinemia and was successfully treated with transfusions from her mother. Relevant clinical findings and laboratory results for this case are summarized and compared to three other previously reported cases; all babies were born from a mother of Hispanic ethnicity.
ConclusionHemolytic disease of the fetus and new born associated with anti-Ge3 is rare but should be considered when working up a broadly reactive RBC antibody screen in women of Hispanic ethnicity. Early identification of pregnant women with anti-Ge3 is recommended for prenatal transfusion planning and close monitoring of the newborn infant for evidence of late-onset anemia.

• 出版日期2013-10