Dynamic ASL and T-2*-Weighted MRI in Exercising Calf Muscle at 7 T-A Feasibility Study

作者：Schewzow Kiril; Fiedler Georg Bernd; Meyerspeer Martin; Goluch Sigrun; Laistler Elmar; Wolzt Michael; Moser Ewald^*; Schmid Albrecht Ingo

来源：Magnetic Resonance in Medicine, 2015, 73(3): 1190-1195.

DOI：10.1002/mrm.25242

• arterial spin labeling
• perfusion
• skeletal muscle
• T-2(*)
• exercise
• plantar flexion
• 7 Tesla

PurposeThe aim of this study was to develop a measurement protocol for noninvasive simultaneous perfusion quantification and T-2*-weighted MRI acquisition in the exercising calf muscle at 7 Tesla.
MethodsUsing a nonmagnetic ergometer and a dedicated in-house built calf coil array, dynamic pulsed arterial spin labeling (PASL) measurements with a temporal resolution of 12 s were performed before, during, and after plantar flexion exercise in 16 healthy volunteers.
ResultsPostexercise peak perfusion in gastrocnemius muscle (GAS) was 27 16 ml/100g/min, whereas in soleus (SOL) and tibialis anterior (TA) muscles it remained at baseline levels. T-2*-weighted and ASL time courses in GAS showed comparable times to peak of 161 +/- 72 s and 167 +/- 115 s, respectively. The T-2*-weighted signal in the GAS showed a minimum during exercise (88 +/- 6 % of the baseline signal) and a peak during the recovery (122 +/- 9%), whereas in all other muscles only a signal decrease was observed (minimum 91 +/- 6% in SOL; 87 +/- 8% in TA).
ConclusionWe demonstrate the feasibility of dynamic perfusion quantification in skeletal muscle at 7 Tesla using PASL. This may help to better investigate the physiological processes in the skeletal muscle and also in diseases such as diabetes mellitus and peripheral arterial disease. Magn Reson Med 73:1190-1195, 2015.

• 出版日期2015-3