科研之友
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摘要
Two new steroidal saponins, diosbulbisides D (1) and E (2), along with five known saponins (3-7) were isolated from the rhizomes of Dioscorea bulbifera L. Their structures were elucidated on the basis of spectral data. Compounds 6 and 7, two 3-O-trisaccharides of diosgenin spirostanes, showed moderate cytotoxic activity against human hepatocellular carcinoma cells, with IC(50) values of 3.89 mu M and 7.47 mu M on SMMC7721, and 10.87 mu M and 19.10 mu M on Bel-7402 cell lines, respectively.
- 出版日期2011-5
- 单位上海中药标准化研究中心; 上海中医药大学
