Diarylheptanoids from the fruits of Amomum kravanh and their inhibitory activities of nitric oxide production

作者：Yin, Hong; Luo, Jian-Guang; Kong, Ling-Yi^*

来源：Phytochemistry Letters, 2013, 6(3): 403-406.

DOI：10.1016/j.phytol.2013.05.004

• Amomum kravanh
• Diarylheptanoids
• Nitric oxide
• RAW264.7 macrophages

Two new diarylheptanoids with a tetrahydropyran ring, kravanhol A (1) and kravanhol B (2), along with one known diarylheptanoid renealtin A (3) were isolated from the fruits of Amomum kravanh. The structures of compounds 1 and 2 were established by analysis of spectroscopic data and their absolute configurations were determined by Mosher's method and CD experiments. Compound 2 showed inhibitory effect on nitric oxide production in lipopolysaccharide-activated RAW264.7 macrophages with an IC50 value of 38.9 +/- 1.8 mu M.

• 出版日期2013-8
• 单位天然药物活性组分与药效国家重点实验室; 中国药科大学