F-18-FET PET/CT in Advanced Head and Neck Squamous Cell Carcinoma: an Intra-individual Comparison with F-18-FDG PET/CT

作者：Haerle Stephan Kurt^*; Fischer Dorothee R; Schmid Daniel T; Ahmad Nader; Huber Gerhard F; Buck Alfred

来源：Molecular Imaging and Biology, 2011, 13(5): 1036-1042.

DOI：10.1007/s11307-010-0419-5

• F-18-FET PET/CT
• F-18-FDG PET/CT
• Tracer
• Head and neck cancer
• Staging

To assess the diagnostic value of O-2-fluoro-18(F)-ethyl-l-tyrosine (F-18-FET) positron emission tomography/computed tomography (PET/CT) for patients with advanced head and neck squamous cell carcinoma compared with 18F-fluoro-2-deoxy-d-glucose (F-18-FDG) PET/CT at initial staging and following radiochemotherapy.
Thirteen patients were prospectively enrolled; each of them underwent an F-18-FDG PET/CT and F-18-FET PET/CT before treatment. Ten of those were scanned 10 weeks after treatment.
Sensitivity, specificity, and accuracy for F-18-FDG PET/CT (primary and lymph node metastases) at initial staging were 89%, 50%, and 81%. For F-18-FET PET/CT the numbers were 70%, 90%, and 74%. Sensitivity, specificity, and accuracy for F-18-FDG PET/CT at follow-up were 71%, 65%, and 67%. For F-18-FET PET/CT the numbers were 29%, 100%, and 83%. Additionally, F-18-FDG PET/CT detected a higher number of second malignancies or distant metastases.
F-18-FET is no substitute for F-18-FDG. Although it is more specific, too many malignant lesions are missed due to its lower sensitivity.

• 出版日期2011-10