Asymmetric construction of trifluoromethylated pyrrolidines via Cu(I)-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with 4,4,4-trifluorocrotonates

作者：Li Qing Hua; Tong Min Chao; Li Jun; Tao Hai Yan; Wang Chun Jiang^*

来源：Chemical Communications, 2011, 47(39): 11110-11112.

DOI：10.1039/c1cc14295j

Trifluoromethylated pyrrolidines have been synthesized via catalytic asymmetric 1,3-dipolar cycloaddition with excellent stereoselectivity for the first time. Epimerization of the endo-pyrrolidines obtained from cis-4,4,4-trifluorocrotonate into the exo-pyrrolidines was also revealed.

• 出版日期2011
• 单位武汉大学