Associations between adiposity and repetitive element DNA methylation in healthy postmenopausal women

作者：Boyne Devon J; Friedenreich Christine M; McIntyre John B; Courneya Kerry S; King Will D^*

来源：Epigenomics, 2017, 9(10): 1267-1277.

DOI：10.2217/epi-2017-0047

• adiposity
• Alu
• body fat
• DNA methylation
• LINE-1
• postmenopausal
• repetitive elements

Aim: To describe the association between adiposity and repetitive element DNA methylation in healthy postmenopausal women. Patients & methods: A cross-sectional study was conducted using baseline information from 289 women who participated in the Alberta Physical Activity and Breast Cancer Prevention trial. Results: After adjusting for important confounders, long interspersed nuclear element-1 methylation was positively associated with intra-abdominal fat area (p = 0.03), body fat percent (p = 0.048), fat mass (p = 0.01), waist circumference (p = 0.03), hip circumference (p = 0.001), BMI (p = 0.03), current weight (p = 0.002), weight at age 20 (p = 0.02) and adulthood weight gain (p = 0.03). No significant associations were found between any of the adiposity measures and Alu methylation. Conclusion: Current and historical adiposity measures are positively associated with long interspersed nuclear element-1 methylation in healthy postmenopausal women.

• 出版日期2017-10