Multivariate control charts based on net analyte signal (NAS) and Raman spectroscopy for quality control of carbamazepine

作者：de Carvalho Rocha Werickson Fortunato; Poppi Ronei Jesus^*

来源：Analytica Chimica Acta, 2011, 705(1-2): 35-40.

DOI：10.1016/j.aca.2011.03.024

• Raman spectroscopy
• Net analyte signal
• Multivariate control charts
• Carbamazepine

Raman spectroscopy and control charts based on the net analyte signal (NAS) were applied to polymorphic characterization of carbamazepine. Carbamazepine presents four polymorphic forms: I-IV (dihydrate). Xray powder diffraction was used as a reference technique. The control charts were built generating three charts: the NAS chart that corresponds to the analyte of interest (form III in this case), the interference chart that corresponds to the contribution of other compounds in the sample and the residual chart that corresponds to nonsystematic variations. For each chart, statistical limits were developed using samples within the quality specifications. It was possible to identify the different polymorphic forms of carbamazepine present in pharmaceutical formulations. Thus, an alternative method for the quality monitoring of the carbamazepine polymorphic forms after the crystallization process is presented.

• 出版日期2011-10-31
• 单位中国计量科学研究院