NON-ENHANCED PATTERN ON CONTRAST-ENHANCED ULTRASOUND IN THE LOCAL EFFICACY ASSESSMENT OF IRREVERSIBLE ELECTROPORATION ABLATION OF PANCREATIC ADENOCARCINOMA

作者：Lin, Manxia; Xie, Xiaoyan; Xu, Ming; Feng, Shiting; Tian, Wenshuo; Zhuang, Bowen; Su, Liya; Ye, Jieyi; Lin, Jinhua; Liang, Ping; Yu, Jie; Kuang, Ming^*

来源：Ultrasound in Medicine and Biology, 2018, 44(9): 1986-1995.

DOI：10.1016/j.ultrasmedbio.2018.05.018

• Irreversible electroporation ablation
• Contrast-enhanced ultrasound
• Pancreatic adenocarcinoma
• Imaging
• Tumor response

The objective was to evaluate the diagnostic value of contrast-enhanced ultrasound in the assessment of the local efficacy after irreversible electroporation (IRE) ablation of pancreatic adenocarcinoma 1 mo after ablation. Fifteen patients with pancreatic adenocarcinoma were treated with IRE and then examined by contrast-enhanced ultrasound 1 mo after ablation. The contrast agent was SonoVue. Technical efficacy was assessed at 3 mo after IRE and classified as technical efficiency (TE) and technical inefficiency (TIE). Diagnostic performance was analyzed using a receiver operating characteristic curve. Ten patients were considered as having TE, and five, TIE. Complete non-enhancement was observed in seven ablation zones (70.0%) in the TE group, and peripheral heterogeneous enhancement, in all five ablation zones (100.0%) in the TIE group. The non-enhancement pattern differed significantly between the TE and TIE groups (p = 0.026), with significant correlation with technical efficacy (p = 0.007). The area under the receiver operating characteristic curve was 0.85 (p = 0.008, 95% confidence interval: 0.65-1.05). A non-enhancement pattern using contrast-enhanced ultrasound was useful in the assessment of local efficacy after IRE ablation of pancreatic adenocarcinoma. (E-mail: [e-mail].

• 出版日期2018-9
• 单位中山大学; 中国人民解放军总医院