Activated microglia in acute encephalopathy with biphasic seizures and late reduced diffusion

作者：Fujita Yuji^*; Takanashi Jun ichi; Takei Haruka; Ota Setsuo; Fujii Katsunori; Sakuma Hiroshi; Hayashi Masaharu

来源：Journal of the Neurological Sciences, 2016, 366: 91-93.

DOI：10.1016/j.jns.2016.04.050

• Encephalopathy
• Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD)
• Microglia
• Glutamate

Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is the most common subtype of infectious pediatric encephalopathy in Japan. The exact pathogenesis of and the best therapeutic strategy for AESD are uncertain. We firstly performed a brain biopsy in a 2-year-old boy with AESD associated with RS viral infection, which revealed activated ameoboid microglia accumulation around degenerated neuron, and astrogliosis in the affected cortex. Glutamate released from activated microglia may play an important role in the pathogenesis of AESD, which is compatible with the previous report of magnetic resonance spectroscopy showing elevated glutamate.

• 出版日期2016-7-15
• 单位河北医科大学