A 6-month study of the effects of 0.3% triclosan/copolymer dentifrice on dental implants

作者：Sreenivasan Prem K; Vered Yuval; Zini Avi; Mann Jonathan; Kolog Hilla; Steinberg Doron; Zambon Joseph J^*; Haraszthy Violet I; da Silva Maike P; De Vizio William

来源：Journal of Clinical Periodontology, 2011, 38(1): 33-42.

DOI：10.1111/j.1600-051X.2010.01617.x

• bacteria
• biofilm
• dental implant
• gingivitis
• triclosan

P>Aim
Supportive therapy to maintain dental implants is increasingly important. This study examined the effect of a 0.3% triclosan/2% copolymer dentifrice on oral biofilms and gingival inflammation (GI) on dental implants and peri-implant tissues.
Materials and Methods
One hundred and twenty adults with a dental implant and contra-lateral tooth were enrolled in this 6 month, double-blind, two-treatment, parallel group study. Sixty subjects were randomly assigned to a triclosan/copolymer dentifrice test group and 60 subjects to a fluoride dentifrice control group and instructed to brush twice daily for 6 months. At baseline, 3, and 6 months, a calibrated dentist assessed dental plaque, GI and collected supragingival dental plaque for microbiological analysis.
Results
Subjects in the triclosan/copolymer group demonstrated significantly lower levels of dental plaque, gingivitis, and bleeding on probing at 3 and 6 months at both the implant and contra-lateral tooth compared with the fluoride group (p < 0.05). There were significantly fewer Gram-negative anaerobes in the triclosan/copolymer group (p < 0.05) including > 90% reductions in Aggregatibacter actinomycetemcomitans, Campylobacter rectus, Eubacterium saburreum, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella melaninogenica, Solobacterium moorei, and Tannerella forsythia.
Conclusions
Twice daily use of a triclosan/copolymer dentifrice may enhance dental implant maintenance by reducing dental plaque and GI.

• 出版日期2011-1