Association of Interleukin-11 with Mortality in Patients with Spontaneous Basal Ganglia Haemorrhage

作者：Tu, C. J.; Liu, W. G.^*; Dong, X. Q.; Liu, J. S.; Song, D. G.; Yu, W. H.; Zhang, Z. Y.; Zhen, G.; Luo, H. M.

来源：Journal of International Medical Research, 2011, 39(4): 1265-1274.

DOI：10.1177/147323001103900414

• INTRACEREBRAL HAEMORRHAGE
• MORTALITY
• INTERLEUKIN-11
• GLASGOW COMA SCALE
• HAEMATOMA VOLUME

This study evaluated interleukin (IL)-11 as an independent prognostic marker of mortality following intracerebral haemorrhage (ICH). Plasma IL-11 levels in patients with ICH were significantly higher than in healthy controls. Multivariate analysis indicated that plasma IL-11 level was an independent predictor for mortality within 1 week of ICH onset and was positively associated with haematoma volume. Receiver operating characteristic curve analysis identified that a baseline plasma IL-11 level > 20.9 pg/ml predicted mortality within 1 week of ICH onset with 81.2% sensitivity and 74.1% specificity. The area under the curve for IL-11 level was significantly smaller than that for the Glasgow Coma Scale score, but similar to that for haematoma volume. IL-11 did not, however, significantly improve the predictive value of the Glasgow Coma Scale or haematoma volume. Thus, IL-11 may be considered as a new independent prognostic marker of mortality and an additional valuable tool for risk stratification and decision-making in the acute phase of ICH.

• 出版日期2011-8
• 单位浙江大学; 杭州市第一人民医院