Highly lubricious poly(vinyl alcohol)-poly(acrylic acid) hydrogels

作者：Choi Jeeyoung; Kung Hsiang J; Macias Celia E; Muratoglu Orhun K^*

来源：Journal of Biomedical Materials Research Part B: Applied Biomaterials , 2012, 100B(2): 524-532.

DOI：10.1002/jbm.b.31980

• hydrogel
• poly(vinyl alcohol)
• poly(acrylic acid)
• lubricity
• creep
• water content
• annealing
• cartilage

Poly(vinyl alcohol) (PVA) hydrogels have desirable characteristics for use as artificial cartilage, such as biocompatibility, high water content, and surface lubricity. However, PVA hydrogels are not strong enough to withstand the demanding load-bearing environment in human joints. Thermal annealing can greatly improve compressive strength, but it also causes substantial loss in water content and lubricity. We demonstrated that incorporating anionic moieties of poly(acrylic acid) improves surface lubricity, whereas adding poly(ethylene-glycol) prevents pore collapse during thermal annealing, yielding a tough hydrogel with high lubricity. We also found a super-lubricous response from the gels when they were annealed in air versus argon gas.

• 出版日期2012-2