科研之友
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摘要
Acute leukemias are the most common cancers of childhood. They are a consequence of malignant transformation of a hematopoietic progenitor cell in the bone marrow. The introduction and optimization of risk-adapted intensive polychemotherapy regimens since the 1970s have substantially increased the chances of survival. Molecular techniques now contribute significantly to the initial risk stratification and response assessment and are critical for therapy adjustment. Current efforts aim to develop effective strategies for still incurable high-risk leukemias and to reduce the considerable toxicities of therapy.
- 出版日期2009-7
