Discovery of new G-quadruplex binding chemotypes

作者：Ohnmacht Stephan A; Varavipour Ehsan; Nanjunda Rupesh; Pazitna Ingrida; Di Vita Gloria; Gunaratnam Mekala; Kumar Arvind; Ismail Mohamed A; Boykin David W; Wilson W David; Neidle Stephen^*

来源：Chemical communications, 2014, 50(8): 960-963.

DOI：10.1039/c3cc48616h

We report here on the discovery and preliminary evaluation of a novel non-macrocyclic low molecular weight quadruplex-stabilizing chemotype. The lead compounds, based on a furan core, show high G-quadruplex stabilisation and selectivity as well as potent in vitro anti-proliferative activity.

• 出版日期2014