Burden of antituberculosis and antiretroviral drug-induced liver injury at a secondary hospital in South Africa

作者：Schutz Charlotte^*; Ismail Zahiera; Proxenos Charles John; Marais Suzaan; Burton Rosie; Kenyon Chris; Maartens Gary; Wilkinson Robert J; Meintjes Graeme

来源：SAMJ South African Medical Journal, 2012, 102(6): 506-511.

DOI：10.7196/SAMJ.5650

Background. G F Jooste Hospital (GFJH) is a secondary-level referral hospital in a high HIV and tuberculosis (TB) co-infection setting. %26lt;br%26gt;Aims. To assess the proportion of significant drug-induced liver injury (DILI) due to tuberculosis treatment (TBT) and/or antiretroviral therapy (ART) among patients presenting with liver dysfunction at GFJH and to describe management and outcomes. %26lt;br%26gt;Methods. A retrospective observational study was performed of all cases referred to GFJH with significant liver dysfunction from 1 January to 30 June 2009. Significant liver dysfunction was defined by alanine transaminase (ALT)%26gt;= 200 U/l or total bilirubin (TBR)%26gt;= 44 mu mol/l. TBT- or ART-associated DILI was defined as significant liver dysfunction attributed to TBT and/or ART and which resulted in the halting of treatment or the adjustment thereof. Outcome measures included case numbers, descriptive data, and in-hospital and 3-month mortality. %26lt;br%26gt;Results. A total of 318/354 cases of significant liver dysfunction were reviewed: 71 were classified as TBT- or ART-associated DILI, while liver dysfunction was attributed to other causes in the remainder. In-hospital and 3-month mortality of TBT- or ART-associated DILI patients was 27% (n=19) and 35% (n=25), respectively. The majority of deaths were related to sepsis or sepsis complicating liver dysfunction. Twenty-three patients (32%) were lost to follow-up; 23 (32%) were alive and in outpatient care 3 months after presentation. %26lt;br%26gt;Conclusions. TBT- or ART-associated DILI is a common reason for presentation at a referral hospital in South Africa. In-hospital and 3-month mortality are high. Prospective studies are needed to define optimal management.

• 出版日期2012-6
• 单位河北医科大学