The Na /K -ATPase is the Achilles Heel of multi-drug-resistant cancer cells

作者：Mijatovic Tatjana; Jungwirth Ute; Heffeter Petra; Hoda Mir Ali Reza; Dornetshuber Rita; Kiss Robert; Berger Walter

来源：Cancer Letters, 2009, 282(1): 30-34.

DOI：10.1016/j.canlet.2009.02.048

• Multi-drug resistance (MDR)
• Cardenolide
• 19-hydroxy-2 '' oxovoruscharin
• Na /K -ATPase targeting

We recently reported that over-expressed Na /K -ATPase alpha subunits are new important anti-cancer targets. Cardiotonic steroids are the natural ligands of Na /K -ATPase and thus potentially potent anti-cancer agents with a novel mechanism of action. We report here that the hemi-synthetic cardenolide 19-hydroxy-2 '' oxovoruscharin is impressively active in cancer cells expressing diverse forms of multi-drug resistance (MDR) either conferred by the over-expression of selected drug-transporter proteins or induced by a range of chemotherapeutic agents. Together with the inability of tumor cells to acquire resistance to 19-hydroxy-2 '' oxovoruscharin, our data suggest that this novel compound could be especially applicable to notoriously drug-resistant cancers.

• 出版日期2009-9-8