Msx2 is required for vascular smooth muscle cells osteoblastic differentiation but not calcification in insulin-resistant ob/ob mice

作者：Andrade Maria Claudina; Carmo Luciana S; Farias Silva Elisangela; Liberman Marcel

来源：Atherosclerosis, 2017, 265: 14-21.

DOI：10.1016/j.atherosclerosis.2017.07.028

• Vascular calcification
• Vascular smooth muscle cells
• Diabetes mellitus
• Osteogenesis

Abstract(#br)Background and aims(#br)Obesity and diabetes potentiate vascular calcification by increasing vascular smooth muscle cells osteoblastic differentiation mediated by the transcription factor Msx2 and bone morphogenetic protein-2 signaling. However, Bmp-2/Msx2 crosstalk to induce VSMC osteo...

• 出版日期2017-10