Association Between Vitamin D Status and COPD Phenotypes

作者：Moberg Mia^*; Ringbaek Thomas; Roberts Nassim Bazeghi; Vestbo Jorgen

来源：Lung, 2014, 192(4): 493-497.

DOI：10.1007/s00408-014-9582-9

• 25(OH)D
• Biomarker
• Seasonality
• COPD
• Vitamin D
• Phenotypes

It has been suggested that identifying phenotypes in chronic obstructive pulmonary disease (COPD) might improve treatment outcome and the accuracy of prediction of prognosis. In observational studies vitamin D deficiency has been associated with decreased pulmonary function, presence of emphysema and osteoporosis, upper respiratory tract infections, and systemic inflammation. This could indicate a relationship between vitamin D status and COPD phenotypes. The aim of this study was to assess the association between vitamin D levels and COPD phenotypes. In addition, seasonality of vitamin D levels was examined.
A total of 91 patients from a Danish subpopulation of the "Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points" cohort took part in a biomarker substudy. Vitamin D concentration was measured from blood samples taken at two visits, approximately 6 months apart. The participants were 40-75-year-old patients with COPD and had a smoking history of > 10 pack-years.
Fifty-six patients had 25-hydroxyvitamin D measured from blood samples from both visits. In the final model of the multivariate analyses, the factors that were associated with vitamin D deficiency at the first visit were age (OR: 0.89, p = 0.02) and summer season (OR: 3.3, p = 0.03). Factors associated with vitamin D level also at the first visit were age (B: 0.9, p = 0.02) and 6 min walking distance (B: 0.05, p = 0.01).
Vitamin D was not associated with COPD phenotypes and season did not seem to be a determinant of vitamin D levels in patients with moderate to severe COPD.

• 出版日期2014-8