Duration of depressive symptoms and mortality risk: the English Longitudinal Study of Ageing (ELSA)

作者：White James^*; Zaninotto Paola; Walters Kate; Kivimaeki Mika; Demakakos Panayotes; Biddulph Jane; Kumari Meena; De Oliveira Cesar; Gallacher John; Batty G David

来源：The British Journal of Psychiatry, 2016, 208(4): 337-+.

DOI：10.1192/bjp.bp.114.155333

Background
The relationship between the duration of depressive symptoms and mortality remains poorly understood.
Aims
To examine whether the duration of depressive symptoms is associated with mortality risk.
Method
Data (n = 9560) came from the English Longitudinal Study of Ageing (ELSA). We assessed depressive symptom duration as the sum of examinations with an eight-item Center for Epidemiologic Studies Depression Scale score of >= 3; we ascertained mortality from linking our data to a national register.
Results
Relative to those participants who never reported symptoms, the age-and gender-adjusted hazard ratios for elevated depressive symptoms over 1, 2, 3 and 4 examinations were 1.41 (95% CI 1.15-1.74), 1.80 (95% CI 1.44-2.26), 1.97 (95% CI 1.57-2.47) and 2.48 (95% CI 1.90-3.23), respectively (P for trend <0.001). This graded association can be explained largely by differences in physical activity, cognitive function, functional impairments and physical illness.
Conclusions
In this cohort of older adults, the duration of depressive symptoms was associated with mortality in a dose-response manner.
Declaration of interest
None.

• 出版日期2016-4