A convenient and efficient synthesis of C-carbamoyl-1,2,3-triazoles from alkyl bromide by a one-pot sequential addition: conversion of ester to amide using Zr(Ot-Bu)(4)

作者：Yang Dongsik; Kwon Mihyun; Jang Yujin; Jeon Heung Bae^*

来源：Tetrahedron Letters, 2010, 51(28): 3691-3695.

DOI：10.1016/j.tetlet.2010.05.046

• One-pot sequence
• C-Carbamoyl-1,2,3-triazole
• Zirconium tert-butoxide
• Microwave irradiation

A convenient and efficient one-pot sequence has been developed for the synthesis of C-carbamoyl-1,2,3-triazoles from alkyl bromide using (i) sodium azide, (ii) methyl propiolate and copper iodide, and (iii) amines, zirconium tert-butoxide, and 1-hydroxybenzotriazole, under microwave irradiation. The sequential reactions in one-pot provided the desired C-carbamoyl-1,2,3-triazoles in excellent yields.

• 出版日期2010-7-14