Protective role of the HLA-A*02 allele in Portuguese patients with multiple sclerosis

作者：Silva A M^*; Bettencourt A; Pereira C; Santos E; Carvalho C; Mendonca D; Costa P P; Monteiro L; Martins B

来源：Multiple Sclerosis, 2009, 15(6): 771-774.

DOI：10.1177/1352458509104588

• genetic susceptibility
• HLA class I
• multiple sclerosis
• Portugal

Background Multiple sclerosis (MS) is associated with human leukocyte antigen (HLA) HLA DRB1*15. Recent evidence that CD8 T cells are implicated in MS suggests that HLA class I may also contribute. An association of HLA-A*02 and A*03 alleles has been described.
Objectives We examined the influence of HLA-A*02 and HLA-A*03 in Portuguese patients with MS, independently of HLA-DRB1*15 using a logistic regression model.
Conclusions DRB1*15 increased the risk of developing MS and HLA-A*02 decreased the risk. A*03 had no effect. To analyze if HLA-A*02 association was independent from DRB1*15, an interaction between these two alleles was introduced in the model; no significant interaction was found. Multiple Sclerosis 2009; 15: 771-774. http://msj.sagepub.com

• 出版日期2009-6