科研之友
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摘要
An efficient potassium persulfate mediated four component reaction for the construction of 5-methyl pyrimidine derivatives has been established from readily available methyl ketones, amidine hydrochlorides and dimethyl sulfoxide. This transformation features dimethyl sulfoxide as a dual synthon, acting as the precursors of the methyl and methine units. Four new chemical bonds, involving two C-C and two C-N bonds were formed sequentially during the intermolecular oxidative annulation process. This synthetic method offers several advantages including broad substrate scope, good functional group tolerance and simplicity of operation.
