Amphiphilic alpha-helix mimetics based on a benzoylurea scaffold

作者：Thompson Sam; Hamilton Andrew D^*

来源：Organic and Biomolecular Chemistry, 2012, 10(30): 5780-5782.

DOI：10.1039/c2ob25273b

The design and synthesis of amphiphilic benzoylurea alpha-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an alpha-helix.

• 出版日期2012