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摘要
The objective of this study was to test the feasibility and reproducibility of in vivo high-resolution mechanical imaging of the asymptomatic human kidney. Hereby nine volunteers were examined at three different physiological states of urinary bladder filling (a normal state, urinary urgency, and immediately after urinary relief). Mechanical imaging was performed of the in vivo kidney using three-dimensional multifrequency magnetic resonance elastography combined with multifrequency dual elastovisco inversion. Other than in classical elastography, where the storage and loss shear moduli are evaluated, we analyzed the magnitude IG*vertical bar and the phase angle phi, of the complex shear modulus reconstructed by simultaneous inversion of full wave field data corresponding to 7 harmonic drive frequencies from 30 to 60 Hz and a resolution of 2.5 mm cubic voxel size. Mechanical parameter maps were derived with a spatial resolution superior to that in previous work. The group-averaged values of IG*vertical bar were 2.67 +/- 0.52 kPa in the renal medulla, 1.64 +/- 0.17 kPa in the cortex, and 1.17 +/- 0.21 kPa in the hilus. The phase angle phi (in radians) was 0.89 +/- 0.12 in the medulla, 0.83 +/- 0.09 in the cortex, and 0.72 +/- 0.06 in the hilus. All regional differences were significant (P < 0.001), while no significant variation was found in relation to different stages of bladder filling. In summary our study provides first high-resolution maps of viscoelastic parameters of the three anatomical regions of the kidney. IG*vertical bar and phi provide novel information on the viscoelastic properties of the kidney, which is potentially useful for the detection of renal lesions or fibrosis.
- 出版日期2014-2-7
- 单位河北医科大学
