Anti-inflammatory steroids from the octocoral Dendronephthya griffini

作者：Chao, Chih Hua; Wen, Zhi Hong; Chen, I Ming; Su, Jui Hsin; Huang, Ho Cheng; Chiang, Michael Y; Sheu, Jyh Horng^*

来源：Tetrahedron, 2008, 64(16): 3554-3560.

DOI：10.1016/j.tet.2008.01.109

• octocoral
• steroid
• griffinisterones A-E
• anti-inflammatory effect

Five new steroids, griffinisterones A-E (1-5), were isolated from the octocoral Dendronephthya griffini. The structures of these compounds were elucidated by extensive spectroscopic analysis. The single-crystal X-ray crystallography on I allowed the determination of the 24R configuration in 1. The absolute stereochemistry of 5 was determined by the application of PGME method. Compounds 3 and 4 were found to significantly inhibit the accumulation of the pro-inflammatory NOS protein of the LPS-stimulated RAW264.7 macrophage cells.

• 出版日期2008-4-14
• 单位中山大学