Avian Influenza A (H7N9) viruses isolated from patients with mild and fatal infection differ in pathogenicity and induction of cytokines

作者：Zhou, Junmei; Guo, Xiaolan; Fang, Danyun; Yu, Yufeng; Si, Lulu; Wang, Ying; Zeng, Gucheng; Yan, Huijun; Wu, Jie; Ke, Changwen^*; Jiang, Lifang^*

来源：Microbial Pathogenesis, 2017, 111: 402-409.

DOI：10.1016/j.micpath.2017.08.022

• CHILDREN
• ORIGIN

Since 2013, a novel Influenza A (H7N9) virus strain has continued to circulate within poultry and causing human disease. Influenza A (H7N9) virus results in two types of infection: mild and severe. The different results of clinical findings may be related with host susceptibility and characteristics of the virus itself. In order to investigate potential pathogenesis of Influenza A (H7N9) virus, we performed pathogenecity and cytolcines analysis of two isolates, A/Guangdong/6/2013 H7N9 virus (GD-6) from a patient with a mild infection, and A/Guangdong/7/2013 H7N9 virus (GD-7) from a patient with a fatal infection. We found that GD-7 replicated to higher levels than GD-6 in human peripheral blood mononuclear cells (PBMCs), lung tissues, and mice. Furthermore, GD-7 infection resulted in more severe lung damage in mice lung tissues than GD-6 infection. GD-7 elicited higher levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha(TNF-alpha) than GD-6 did. In conclusion, GD-7 was more pathogenic and induced higher levels of proinflammatory cytokines than GD-6 did.

• 出版日期2017-10
• 单位广东省疾病预防控制中心; 广州医科大学; 中山大学