Development of the custom polymeric materials specific for aflatoxin B1 and ochratoxin A for application with the ToxiQuant T1 sensor tool

作者：Piletska Elena^*; Karim Kal; Coker Raymond; Piletsky Sergey

来源：Journal of Chromatography A, 2010, 1217(16): 2543-2547.

DOI：10.1016/j.chroma.2009.11.091

• Mycotoxins
• Aflatoxin B1
• Ochratoxin A
• Computational modelling
• Solid-phase extraction

Two polymers were computationally designed with affinity to two of the most abundant mycotoxins aflatoxin B1 (AFB1) and ochratoxin A (OTA) for application in the ToxiQuant T1 System. The principle of quantification of AFB1 and OTA using the ToxiQuant T1 instrument comprised of a fluorimetric analysis of mycotoxins adsorbed on the polymer upon exposure to UV light. High affinity of the developed resins allowed the adsorption of both toxins as discrete bands on the top of the cartridge with detection limit as low as 1 ng quantity of mycotoxins.

• 出版日期2010-4-16