Ultrasound-assisted tandem reaction of alkynes and trihaloisocyanuric acids by thiourea as catalyst in water

作者：Zhang, Xingyu; Wu, Yundong; Zhang, Ya; Liu, Huilan; Xie, Ziyu; Fu, Shengmin; Liu, Fang^*

来源：Tetrahedron, 2017, 73(31): 4513-4518.

DOI：10.1016/j.tet.2017.05.075

• Ultrasound
• Alkyne
• Thiourea
• Trihaloisocyanuric acid
• alpha,alpha-dihaloketones

With water as the sole solvent, a green and efficient method has been developed for the synthesis of various alpha,alpha-dihaloketones via ultrasound assisted p-tolylthiourea catalyzed tandem reaction of alkynes with trihaloisocyanuric acids. This synthetic route could effectively avoid the use of toxic organic solvents and transition metal catalysts, and the products could be obtained in a very short time at room temperature with good to excellent yields.

• 出版日期2017-8-3
• 单位湖南科技学院; 铜仁学院