Promotion effect of acankoreoside J, a lupane-triterpene in Acanthopanax koreanum, on hair growth

作者：Kim Sang Cheol; Kang Jung Il; Park Doek Bae; Lee Young Ki; Hyun Jin Won; Koh Young Sang; Yoo Eun Sook; Kim Jeong Ah; Kim Young Ho; Kang Hee Kyoung^*

来源：Archives of Pharmacal Research, 2012, 35(8): 1495-1503.

DOI：10.1007/s12272-012-0820-5

• Acanthopanax koreanum
• Hair growth
• Acankoreoside J
• Vibrissa follicle
• Dermal papilla cell
• beta-catenin
• Cell cycle progression

This study was conducted to evaluate the effect of Acanthopanax koreanum and acankoreoside J from A. koreanum on the promotion of hair growth. When immortalized rat vibrissa dermal papilla cells were treated with extract of A. koreanum leaves, the proliferation of dermal papilla cells significantly increased. In particular, acankoreoside J among several components, isolated from A. koreanum leaves, markedly promoted the proliferation of the dermal papilla cells. When rat vibrissa follicles were treated with an acankoreoside J, the hair-fiber lengths of the vibrissa follicles increased significantly. We further investigated beta-catenin pathway and cell cycle regulation with respect to the effect of acankoreoside J on the proliferation of the dermal papilla cells. Treatment with acankoreoside J results in an increase of nuclear beta-catenin level, and up-regulation of cyclin D1, cyclin E and CDK2, whereas, the expression of p27(kip1) was down-regulated in the dermal papilla cells. Taken together, these results suggest that acankoreoside J, a lupane-triterpene of A. koreanum, has the potential of promoting hair growth by promoting cell cycle progression of the dermal papilla cells, through the increase of nuclear beta-catenin, along with the up-regulation of cyclin D1, cyclin E and CDK2, and down-regulation of p27(kip1).

• 出版日期2012-8
• 单位河北医科大学