Naked eye sensing of toxic metal ions in aqueous medium using thiophene-based ligands and its application in living cells

作者：Udhayakumari Duraisamy; Suganya Sivalingam; Velmathi Sivan^*; MubarakAli Davoodbasha

来源：Journal of Molecular Recognition, 2014, 27(3): 151-159.

DOI：10.1002/jmr.2343

• chromogenic sensor
• schiff base
• cation recognition
• aqueous medium
• DFT
• living cells

Thiophene-based diimine (R1) and monoimine (R2) were synthesized in a single step, and their cation binding affinity was tested using colorimetric and UV-vis spectral studies. R1 selectively shows a colorimetric turn-on response for Pb2+, Hg2+ ions and colorimetric turn-off with Sn2+ ions, and R2 shows visual response for Cu2+ and Hg2+ over other examined metal ions in aqueous medium. R1 forms 1:1 complex with Pb2+, Hg2+, and Sn2+ and exhibits fluorescence quenching, whereas R2 shows 2:1 complex with Hg2+, Cu2+ and shows fluorescence enhancement. The structural and electronic properties of the sensors and their metal complexes were also investigated using Density Functional Theory calculations. R2 was also successfully demonstrated as a fluorescent probe for detecting Cu2+ ions in living cells.

• 出版日期2014-3