Amphiphilic nanoparticles based on poly(vinyl pyrrolidone) and stearoyl modified chitosan as drug vehicles for paclitaxel delivery

作者：Liu, Zhao; Zhang, Teng^*; Tang, Cui^*; Yin, Chunhua

来源：Materials Letters, 2016, 185: 226-229.

DOI：10.1016/j.matlet.2016.08.145

• Polymers
• Nanoparticles
• Hydrophilic modification
• Hydrophobic modification
• Antitumor efficacy

Poly(vinyl pyrrolidone) (PVP) and stearoyl chloride (SC) double-grafted chitosan (PCS) nanoparticles (NPs) were prepared for paclitaxel (PTX) delivery. PTX could be effectively loaded into PCS NPs with encapsulation efficiency of 92.8%. PTX-loaded PCS NPs (PTX/PCS NPs), which possessed particle sizes of 144 nm and Zeta potentials of -7.5 mV, exhibited a sustained release behavior. In H-22 tumor bearing mice, significantly enhanced antitumor efficacies were achieved by PTX/PCS NPs with the tumor inhibition ratio (TIR) of 76.1% as compared with PTX injection. Furthermore, no signs of sub-acute toxicity were detected in healthy mice, indicating the safety of PCS NPs. Therefore, PCS NPs could be served as an effective and safe carrier for PTX delivery.

• 出版日期2016-12-15
• 单位复旦大学; 上海中医药大学