Adding ductus venosus blood flow as a categorical variable to the Combined and Integrated tests in Down%26apos;s syndrome screening

作者：Wald Nicholas J^*; Bestwick Jonathan P; Borrell Antoni

来源：Journal of Medical Screening, 2012, 19(1): 49-50.

DOI：10.1258/jms.2011.011084

Duck%26apos;s venosus blood flow, expressed as a pulsatility index (DVPI) has been shown to improve the performance of the Combined and Integrated antenatal screening tests for Down%26apos;s syndrome using previously published data. The use of ductus venosus blood flow as a categorical marker (reversed or absent end diastolic blood flow indicating a positive result) is less discriminatory but simpler, so is sometimes preferred over DVPI. For example, with the Integrated test the false-positive rate for a 90% detection rate was 1.5% as a categorical marker compared with 1.1% expressed as DVPI. We here provide the necessary algorithm and parameters for using ductus venosus blood flow as a categorical marker with the Combined and Integrated tests.

• 出版日期2012