New insights into the regulation and cellular functions of the ARP2/3 complex

作者：Rotty Jeremy D; Wu Congying; Bear James E^*

来源：Nature Reviews Molecular Cell Biology, 2013, 14(1): 7-12.

DOI：10.1038/nrm3492

The actin-related protein 2/3 (ARP2/3) complex nucleates branched actin filament networks, but requires nucleation promoting factors (NPFs) to stimulate this activity. NPFs include proteins such as Wiskott-Aldrich syndrome protein (WASP), neural WASP (NWASP), WASP family verprolin-homologous protein (WAVE; also known as SCAR) and the recently identified WASP and SCAR homologue (WASH) complex. The mechanisms underlying NPF-dependent regulation and the cellular functions of ARP2/3 are being unravelled using new chemical and genetic approaches. Of particular interest is the role of the ARP2/3 complex in vesicular trafficking and directional cell motility.

• 出版日期2013-1