Diastereoselective syntheses of chroman spiroketals via [4+2] cycloaddition of enol ethers and o-quinone methides

作者：Marsini Maurice A; Huang Yaodong; Lindsey Christopher C; Wu Kun Liang; Pettus Thomas R R^*

来源：Organic Letters, 2008, 10(7): 1477-1480.

DOI：10.1021/ol8003244

A variety of chroman spiroketals are synthesized via inverse-demand [4 + 2] cycloaddition of enol ethers and ortho-quinone methides (o-QMs). Low temperature o-QM generation in situ allows for the kinetic, diastereoselective construction of these motifs, providing entry to a number of unusual chroman spiroketal natural products.

• 出版日期2008-4-3