Antigenic and Genetic Variation in the Hemagglutinins of H1N1 and H3N2 Human Influenza A Viruses in the Shanghai Area From 2005 to 2008

作者：Ren Xiao wei; Ju Li wen; Yang Ji xing; Lv Xi hong; Jiang Lu fang; Zhao Nai qing^*; Jiang Qing wu

来源：Journal of Medical Virology, 2011, 83(7): 1113-1120.

DOI：10.1002/jmv.22078

• influenza virus
• antigenic cartography
• hemagglutinin
• Shanghai

Continued rapid evolution of the influenza A virus is responsible for annual epidemics and occasional pandemics in the Shanghai area. In the present study, the representative strains of A/H1N1 and A/H3N2 influenza viruses isolated in the Shanghai area from 2005 to 2008 were antigenically and genetically characterized. The antigenic cartography method was carried out to visualize the hemagglutination-inhibition data. Antigenic differences were detected between circulating A/H1N1 strains isolated from 2005 to 2006 and the epidemic A/H1N1 strains isolated in 2008, which were found to be associated with the amino acid substitution K140E in HA1. The present vaccine strain A/Brisbane/59/2007 is considered to be capable of providing sufficient immunity against most of the circulating A/H1N1 viruses isolated in 2008 from the Shanghai population. The study showed that there were significant antigenic differences between the epidemic A/H3N2 strains isolated in 2007 and 2008, suggesting that antigenic drift had occurred in the A/H3N2 strains isolated in 2008. The P194L mutation was thought to be responsible for the antigenic evolution of influenza A/H3N2 viruses isolated from Shanghai in 2008. Evidence of antigenic drift suggests that the influenza A/H3N2 vaccine component needs to be updated. J. Med. Virol. 83:1113-1120, 2011.

• 出版日期2011-7
• 单位复旦大学