Use of a Cyclometalated Iridium(III) Complex Containing a N boolean AND C boolean AND N-Coordinating Terdentate Ligand as a Catalyst for the alpha-Alkylation of Ketones and N-Alkylation of Amines with Alcohols

作者：Liu, Pengcheng; Lang, Ran; Lu, Lei; Yu, Zhentao; Li, Feng^*

来源：Journal of Organic Chemistry, 2017, 82(4): 1943-1950.

DOI：10.1021/acs.joc.6b02758

• TRANSITION-METAL
• CHEMOSELECTIVE HYDROGENATION
• SELECTIVE ALKYLATION
• RECYCLABLE CATALYST
• REDUCTIVE AMINATION
• EFFICIENT CATALYSTS
• BORROWING HYDROGEN
• PALLADIUM CATALYST
• HIGHLY EFFICIENT
• WATER OXIDATION

A cyclometalated iridium(III) complex containing a N boolean AND C boolean AND N-coordinating terdentate ligand [Ir(dpyx-N,C,N)-Cl(mu-Cl)](2) was found to be a general and highly effective catalyst for the a-alkylation of ketones and N-alkylation of amines with alcohols. In the presence of catalyst (1 mol % Ir) and base (0.2-0.5 equiv), a variety of desirable products were obtained in good yields under an air atmosphere. Notably, this research exhibited the new potential of Ir(III) complexes bearing non-Cp* ligand and will facilitate the progress of the hydrogen autotransfer process.

• 出版日期2017-2-17
• 单位南京大学; 南京理工大学