Double primary cancer of the esophagus consisting of ectopic gastric mucosa-derived adenocarcinoma and squamous cell carcinoma: a first case report

作者：Iitaka Daisuke; Fujiwara Hitoshi^*; Shiozaki Atsushi; Kubota Takeshi; Ando Takashi; Murayama Yasutoshi; Komatsu Shuhei; Kuriu Yoshiaki; Ikoma Hisashi; Nakanishi Masayoshi; Ichikawa Daisuke; Okamoto Kazuma; Ochiai Toshiya; Kokuba Yukihito; Otsuji Eigo

来源：Esophagus, 2011, 8(4): 303-309.

DOI：10.1007/s10388-011-0296-2

• Esophageal cancer
• Ectopic gastric mucosa
• Adenocarcinoma
• Squamous cell carcinoma

Most esophageal cancers are either squamous cell carcinomas or Barrett's mucosa-derived adenocarcinomas. A 64-year-old man with a long history of alcohol drinking and smoking was found to have a tumor in the cervical esophagus on screening esophagography. Subsequent work-up revealed double primary cancer of the esophagus consisting of adenocarcinoma arising from ectopic gastric mucosa in the cervical esophagus and squamous cell carcinoma in the abdominal esophagus. He underwent subtotal esophagectomy. On microscopic examination of the resected specimen, the Ip tumor in the cervical esophagus was confirmed to be an adenocarcinoma derived from ectopic gastric mucosa that had invaded the muscularis mucosa, and the 0-IIb tumor located near the esophagogastric junction was confirmed to be a squamous cell carcinoma that had invaded the proper mucosal layer. No lymph node metastases were noted. Adenocarcinoma from ectopic gastric mucosa is rare, and its coexistence with squamous cell carcinoma is extremely rare.

• 出版日期2011-12