Antithrombotic Activity of a New Benzimidazole Derivative in the Thrombosis Model in Mice

作者：Smirnov A V; Kucheryavenko A F^*; Spasov A A

来源：Bulletin of Experimental Biology and Medicine, 2014, 157(5): 580-582.

DOI：10.1007/s10517-014-2620-z

• antithrombotic activity
• thrombosis
• platelet aggregation
• RU-891
• acetylsalicylic acid

Antithrombotic activity of a new benzimidazole derivative RU-891, characterized by antiaggregant activity, vs. reference drug acetylsalicylic acid was studied on the epinephrinecollagen thrombosis model in mice. Antithrombotic activity of RU-891 3-fold surpassed that of the reference drug. Histological studies showed that RU-891 significantly reduced the relative and mean areas of thrombi in sections of mouse lungs in comparison with the control.

• 出版日期2014-9