Acceleration of small bowel transit in a canine hypermotility model with intestinal electrical stimulation

作者：Wang, Wei Feng; Yin, Jie Yun; Chen, Jian De Dz^*

来源：Journal of Digestive Diseases, 2015, 16(3): 135-142.

DOI：10.1111/1751-2980.12220

• hypermotility
• intestinal electrical stimulation
• small intestine transit

ObjectiveFew studies have been performed on the effect of intestinal electrical stimulation (IES) on intestinal dysmotility. This study aimed to investigate the small intestine transit (SIT) in a canine model of intestinal hypermotility when applying IES.
MethodSix hound bitches were surgically prepared with two chronic intestinal fistulas, intestinal serosal electrodes of which the proximal pair was used for serosal IES. Pacing wires were attached to a manometric catheter for mucosal IES. A nitrogen oxide synthase inhibitor, N-nitro-L-arginine (LNNA) was used to induce intestinal motility. SIT was measured during IES. The study consisted of four randomized sessions: session 1 (LNNA), session 2 (LNNA plus serosal IES), session 3 (LNNA plus mucosal IES) and session 4 (control).
ResultsThe intestine transit was slowed down from 31.76.1min in the control session to 49.0 +/- 6.2min after using LNNA (P=0.003). Both mucosal and serosal IES accelerated SIT compared with the LNNA session. The SIT time was reduced to 17.7 +/- 3.4min in the mucosal IES session (P=0.006 vs LNNA) and 27.5 +/- 6.3min in the serosal IES session (P=0.020 vs LNNA). No difference was noted in the SIT time between mucosal and serosal IES (P=0.128).
ConclusionIES significantly accelerates delayed SIT in a hypermotility model and intraluminal stimulation is as effective as a serosal one for IES, suggesting that IES may have a therapeutic potential for improving intestinal motility.

• 出版日期2015-3
• 单位中国人民解放军总医院