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摘要
A liquid chromatographic method has been described for the determination of atomoxetine in pharmaceuticals and human plasma. Plasma samples were analyzed after a simple, one step protein precipitation with methanol, and chromatographic separation of atomoxetine and carbamazepine (internal standard) was carried out using the optimum mobile phase of a methanol/acetonitrile/phosphate buffer (10mM, pH 3.0) (35:15:50, v/v/v). Limit of quantification values were 45.2 and 49.5ng/mL for atomoxetine in the mobile phase and human plasma, respectively. Fully validated method is reproducible and selective for the determination of atomoxetine in pharmaceuticals and human plasma.
- 出版日期2010
