Association between Extreme Values of Markers of Chronic Kidney Disease: Mineral and Bone Disorder and 5-Year Mortality among Prevalent Hemodialysis Patients

作者：Zhu, Jin-Gang; Chen, Jin-Bor; Cheng, Ben-Chung; Lee, Chih-Hsiung; Long, Gang; Chien, Yu-Shu^*

来源：Blood Purification, 2018, 45(1-3): 1-7.

DOI：10.1159/000478972

• HD
• Mortality
• Calcium
• Phosphate
• Parathyroid hormone

Background/Aims: We examined the association between markers of chronic kidney disease - mineral and bone disorder (CKD-MBD) and mortality in hemodialysis (HD) patients. Methods: We retrospectively reviewed the association between markers of CKD-MBD and mortality in 1,126 HD patients from 2009 to 2013 with baseline (B), time-average (TA), and time-dependent (TD) Cox regression models. Results: Hypercalcemia (10.9-11.9 mg/dL) indicated an increased risk of all-cause mortality (TA: hazard ratio [HR] 3.49; p = 0.01). Hypophosphatemia (2.0-2.5 mg/dL) was significantly associated with an increased risk of all-cause mortality (TA: HR 5.18; p = 0.01). Hypophosphatemia (<2.0 mg/dL) was significantly associated with an increased risk of cardiovascular mortality in all models. Intact parathyroid hormone levels <60 and >1,500 pg/mL indicated an increased risk of all-cause mortality (TA: HR 1.64; p = 0.02; TD: HR 2.26; p = 0.02). Conclusion: Extreme values of CKD-MBD markers are associated with mortality risk in HD patients.

• 出版日期2018
• 单位天津市人民医院; 长春大学