The relationship between follicle development and progesterone receptor membrane component-1 expression in women undergoing in vitro fertilization

作者：Elassar Alyaa; Liu Xiufang; Scranton Victoria; Wu Carol A; Peluso John J^*

来源：Fertility and Sterility, 2012, 97(3): 572-578.

DOI：10.1016/j.fertnstert.2011.12.026

• PGRMC1
• granulosa/luteal cells
• IVF
• controlled ovarian hyperstimulation
• follicular development

Objective: To determine the relationship between progesterone receptor membrane component-1 (PGRMC1) expression and the outcome of IVF treatment. %26lt;br%26gt;Design: A prospective study in which PGRMC1 messenger RNA (mRNA) levels, methylation status of the Pgrmc1 promoter, and the presence of point mutations within Pgrmc1 were obtained from granulosa (GC)/luteal cells of women undergoing controlled ovarian hyperstimulation (COH). %26lt;br%26gt;Setting: Fertility center/basic science laboratory. %26lt;br%26gt;Patient(s): Eighty-five patients undergoing IVF treatment and 10 women who were undergoing COH for the purpose of oocyte donation were included in this study. %26lt;br%26gt;Intervention(s): None. %26lt;br%26gt;Main Outcome Measure(s): The PGRMC1 measurements were correlated with clinical outcomes, such as number of follicles, number of retrieved oocytes, and ongoing pregnancy rates (PR). %26lt;br%26gt;Result(s): The PGRMC1 mRNA levels within GC/luteal cells of 18% of IVF patients were %26gt;2.25-fold higher than those of oocyte donors. Individuals with elevated PGRMC1 mRNA levels had 30% fewer large follicles and fewer oocytes retrieved. The elevated PGRMC1 mRNA levels were associated with an increase in the methylation of Pgrmc1 promoter. %26lt;br%26gt;Conclusion(s): In patients with elevated PGRMC1 mRNA levels, gonadotropin-induced follicle development is attenuated, although sufficient numbers of follicles develop to allow for ET and subsequent pregnancy. (Fertil Steril (R) 2012;97:572-8.

• 出版日期2012-3